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Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor.

ABSTRACT: The absolute stereo structure of the natural product laurenditerpenol (1S, 6R, 7S, 10R, 11R, 14S, 15R) has been accomplished from eight plausible stereoisomers by its first asymmetric total synthesis in a highly convergent and flexible synthetic pathway. Six stereoisomers of laurenditerpenol were synthesized and evaluated for their biological activity.

SUBMITTER: Chittiboyina AG

PROVIDER: S-EPMC2911032 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

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Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor.

Chittiboyina Amar G AG Kumar Gundluru Mahesh GM Carvalho Paulo B PB Liu Yang Y Zhou Yu-Dong YD Nagle Dale G DG Avery Mitchell A MA

Journal of medicinal chemistry 20071116 25

The absolute stereo structure of the natural product laurenditerpenol (1S, 6R, 7S, 10R, 11R, 14S, 15R) has been accomplished from eight plausible stereoisomers by its first asymmetric total synthesis in a highly convergent and flexible synthetic pathway. Six stereoisomers of laurenditerpenol were synthesized and evaluated for their biological activity. ...[more]

PMID: 18004798

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