Ontology highlight
ABSTRACT:
SUBMITTER: Fang M
PROVIDER: S-EPMC2680114 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Fang Ming M Ren Hongyan H Liu Jiabin J Cadigan Ken M KM Patel Sanjeevkumar R SR Dressler Gregory R GR
Development (Cambridge, England) 20090601 11
Development of the fruit fly Drosophila depends in part on epigenetic regulation carried out by the concerted actions of the Polycomb and Trithorax group of proteins, many of which are associated with histone methyltransferase activity. Mouse PTIP is part of a histone H3K4 methyltransferase complex and contains six BRCT domains and a glutamine-rich region. In this article, we describe an essential role for the Drosophila ortholog of the mammalian Ptip (Paxip1) gene in early development and imagi ...[more]