Ontology highlight
ABSTRACT:
SUBMITTER: Boddey JA
PROVIDER: S-EPMC2682620 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Boddey Justin A JA Moritz Robert L RL Simpson Richard J RJ Cowman Alan F AF
Traffic (Copenhagen, Denmark) 20081204 3
The intracellular survival of Plasmodium falciparum within human erythrocytes is dependent on export of parasite proteins that remodel the host cell. Most exported proteins require a conserved motif (RxLxE/Q/D), termed the Plasmodium export element (PEXEL) or vacuolar targeting sequence (VTS), for targeting beyond the parasitophorous vacuole membrane and into the host cell; however, the precise role of this motif in export is poorly defined. We used transgenic P. falciparum expressing chimeric p ...[more]