Ontology highlight
ABSTRACT:
SUBMITTER: Russo I
PROVIDER: S-EPMC2826791 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Russo Ilaria I Babbitt Shalon S Muralidharan Vasant V Butler Tamira T Oksman Anna A Goldberg Daniel E DE
Nature 20100201 7281
During their intraerythrocytic development, malaria parasites export hundreds of proteins to remodel their host cell. Nutrient acquisition, cytoadherence and antigenic variation are among the key virulence functions effected by this erythrocyte takeover. Proteins destined for export are synthesized in the endoplasmic reticulum (ER) and cleaved at a conserved (PEXEL) motif, which allows translocation into the host cell via an ATP-driven translocon called the PTEX complex. We report that plasmepsi ...[more]