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The effect of blastomere biopsy on preimplantation mouse embryo development and global gene expression.


ABSTRACT: The blastomere biopsy procedure does not affect preimplantation embryo development or global patterns of gene expression in a mouse model of Preimplantation Genetic Testing (PGT). However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching.

SUBMITTER: Duncan FE 

PROVIDER: S-EPMC2683241 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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The effect of blastomere biopsy on preimplantation mouse embryo development and global gene expression.

Duncan Francesca E FE   Stein Paula P   Williams Carmen J CJ   Schultz Richard M RM  

Fertility and sterility 20080906 4 Suppl


The blastomere biopsy procedure does not affect preimplantation embryo development or global patterns of gene expression in a mouse model of Preimplantation Genetic Testing (PGT). However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching. ...[more]

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