Ontology highlight
ABSTRACT:
SUBMITTER: Israel S
PROVIDER: S-EPMC6746714 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Israel Steffen S Ernst Mathias M Psathaki Olympia E OE Drexler Hannes C A HCA Casser Ellen E Suzuki Yutaka Y Makalowski Wojciech W Boiani Michele M Fuellen Georg G Taher Leila L
Scientific reports 20190916 1
Early mouse embryos have an atypical translational machinery that consists of cytoplasmic lattices and is poorly competent for translation. Hence, the impact of transcriptomic changes on the operational level of proteins is predicted to be relatively modest. To investigate this, we performed liquid chromatography-tandem mass spectrometry and mRNA sequencing at seven developmental stages, from the mature oocyte to the blastocyst, and independently validated our data by immunofluorescence and qPCR ...[more]