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Evolution of thermal response properties in a cold-activated TRP channel.

ABSTRACT: Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in frogs versus mammals or birds, consistent with variations in these species' cutaneous and core body temperatures. Thus, somatosensory receptors are not static through evolution, but show functional diversity reflecting the characteristics of an organism's ecological niche.

SUBMITTER: Myers BR

PROVIDER: S-EPMC2683941 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Evolution of thermal response properties in a cold-activated TRP channel.

Myers Benjamin R BR Sigal Yaron M YM Julius David D

PloS one 20090529 5

Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in frogs versus mammals or birds, consistent with variations in these species' cutaneous and core body temperatures. Thus, somatosensory receptors are not static through evolution, but show functional d ...[more]

PMID: 19492038

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