Ontology highlight
ABSTRACT:
SUBMITTER: Verma A
PROVIDER: S-EPMC2684029 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Verma Ayush A Uzun Oktay O Hu Yuhua Y Hu Ying Y Han Hee-Sun HS Watson Nicki N Chen Suelin S Irvine Darrell J DJ Stellacci Francesco F
Nature materials 20080525 7
Nanoscale objects are typically internalized by cells into membrane-bounded endosomes and fail to access the cytosolic cell machinery. Whereas some biomacromolecules may penetrate or fuse with cell membranes without overt membrane disruption, no synthetic material of comparable size has shown this property yet. Cationic nano-objects pass through cell membranes by generating transient holes, a process associated with cytotoxicity. Studies aimed at generating cell-penetrating nanomaterials have fo ...[more]