Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC2686088 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Huang Xudong X Finerty Patrick P Walker John R JR Butler-Cole Christine C Vedadi Masoud M Schapira Matthieu M Parker Sirlester A SA Turk Benjamin E BE Thompson Debra A DA Dhe-Paganon Sirano S
Journal of structural biology 20081105 2
The mammalian ortholog of the retroviral oncogene v-Eyk, and a receptor tyrosine kinase upstream of antiapoptotic and transforming signals, Mer (MerTK) is a mediator of the phagocytic process, being involved in retinal and immune cell clearance and platelet aggregation. Mer knockout mice are viable and are protected from epinephrine-induced pulmonary thromboembolism and ferric chloride-induced thrombosis. Mer overexpression, on the other hand, is associated with numerous carcinomas. Although Mer ...[more]