Ontology highlight
ABSTRACT:
SUBMITTER: Mokas S
PROVIDER: S-EPMC2688547 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Mokas Sophie S Mills John R JR Garreau Cristina C Fournier Marie-Josée MJ Robert Francis F Arya Prabhat P Kaufman Randal J RJ Pelletier Jerry J Mazroui Rachid R
Molecular biology of the cell 20090415 11
Cytoplasmic stress granules (SGs) are specialized regulatory sites of mRNA translation that form under different stress conditions known to inhibit translation initiation. The formation of SG occurs via two pathways; the eukaryotic initiation factor (eIF) 2alpha phosphorylation-dependent pathway mediated by stress and the eIF2alpha phosphorylation-independent pathway mediated by inactivation of the translation initiation factors eIF4A and eIF4G. In this study, we investigated the effects of targ ...[more]