Exploiting the promiscuity of imatinib.
Ontology highlight
ABSTRACT:
SUBMITTER: Lee SJ
PROVIDER: S-EPMC2689438 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Exploiting the promiscuity of imatinib.
Lee Shun J SJ Wang Jean Y J JY
Journal of biology 20090415 3
The protein kinase inhibitor imatinib, also known as Gleevec, has been a notable success in treating chronic myelogenous leukemia. A recent paper in BMC Structural Biology reports a 1.75 A crystal structure of imatinib bound to the oxidoreductase NQO2 and reveals insights into the binding specificity and the off-target effects of the inhibitor. ...[more]
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