Ontology highlight
ABSTRACT:
SUBMITTER: Pandya C
PROVIDER: S-EPMC4215207 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Pandya Chetanya C Farelli Jeremiah D JD Dunaway-Mariano Debra D Allen Karen N KN
The Journal of biological chemistry 20140910 44
Catalytic promiscuity and substrate ambiguity are keys to evolvability, which in turn is pivotal to the successful acquisition of novel biological functions. Action on multiple substrates (substrate ambiguity) can be harnessed for performance of functions in the cell that supersede catalysis of a single metabolite. These functions include proofreading, scavenging of nutrients, removal of antimetabolites, balancing of metabolite pools, and establishing system redundancy. In this review, we presen ...[more]