Ontology highlight
ABSTRACT:
SUBMITTER: Lam BJ
PROVIDER: S-EPMC2695811 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Nature biotechnology 20090222 3
RNA enzymes have been developed that undergo self-sustained replication at a constant temperature in the absence of proteins. These RNA molecules amplify exponentially through a cross-replicative process, whereby two enzymes catalyze each other's synthesis by joining component oligonucleotides. Other RNA enzymes have been made to operate in a ligand-dependent manner by combining a catalytic domain with a ligand-binding domain (aptamer) to produce an 'aptazyme'. The principle of ligand-dependent ...[more]