Ontology highlight
ABSTRACT:
SUBMITTER: Olea C
PROVIDER: S-EPMC3357125 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Olea Charles C Horning David P DP Joyce Gerald F GF
Journal of the American Chemical Society 20120507 19
A nuclease-resistant RNA enzyme, constructed entirely from L-ribonucleotides, was shown to undergo ligand-dependent, self-sustained replication with exponential growth. The catalytic motif is based on a previously described RNA ligase that can undergo either self- or cross-replication but had been limited in its application to ligand sensing due to its susceptibility to degradation by ribonucleases. The self-replicating RNA enzyme and its RNA substrates were prepared synthetically from either D- ...[more]