Ontology highlight
ABSTRACT:
SUBMITTER: Gonzales EB
PROVIDER: S-EPMC2696071 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Neuroscience letters 20071203 2
The presence of phenylalanine (F) at the 6' position of transmembrane domain 2 (TM2) in the alpha4 subunit of alpha4beta2 nicotinic receptors enhances desensitization. As the GABA A receptor affords the ability to study the influence of as few as one and as many as five Fs at this position, we have used it to investigate potential subunit- and stoichiometry-dependent effects of the TM2 6'F mutation on desensitization. Whereas the presence of one F at this position decreased extent of desensitiza ...[more]