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Detection of breast cancer microcalcifications using a dual-modality SPECT/NIR fluorescent probe.


ABSTRACT: Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized.

SUBMITTER: Bhushan KR 

PROVIDER: S-EPMC2696399 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Detection of breast cancer microcalcifications using a dual-modality SPECT/NIR fluorescent probe.

Bhushan Kumar R KR   Misra Preeti P   Liu Fangbing F   Mathur Sanjeev S   Lenkinski Robert E RE   Frangioni John V JV  

Journal of the American Chemical Society 20081201 52


Efficient chemical synthesis of a trifunctional, hydroxyapatite-binding molecule, which provides simultaneous in vivo imaging by NIR fluorescence and SPECT/CT has been described. Quantitation by SPECT provides the "gold standard" by which NIR fluorescence tomography of breast cancer microcalcifications can now be compared and optimized. ...[more]

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