Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4710472 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Zhang Yi Y Xiao Li L Popovic Kosta K Xie Xiuzhen X Chordia Mahendra D MD Chung Leland W K LW Williams Mark B MB Yue Wei W Pan Dongfeng D
Bioorganic & medicinal chemistry letters 20131001 23
Synthesis, characterization, in vitro and in vivo biological evaluation of a heptamethine cyanine based dual-mode single-photon emission computed tomography (SPECT)/near infrared fluorescence (NIRF) imaging probe (99m)Tc-PC-1007 is described. (99m)Tc-PC-1007 exhibited preferential accumulation in human breast cancer MCF-7 cells. Cancer-specific SPECT/CT and NIRF imaging of (99m)Tc-PC-1007 was performed in a breast cancer xenograft model. The probe uptake ratio of tumor to control (spinal cord) w ...[more]