Ontology highlight
ABSTRACT:
SUBMITTER: Tressel SL
PROVIDER: S-EPMC2699463 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Tressel Sarah L SL Huang Ruo-Pan RP Tomsen Nicholas N Jo Hanjoong H
Arteriosclerosis, thrombosis, and vascular biology 20070802 10
<h4>Objective</h4>Fluid shear stress plays a role in angiogenesis. Laminar shear stress (LS) promotes endothelial cell (EC) quiescence, whereas oscillatory shear stress (OS) promotes EC turnover and dysfunction, which could lead to pathological angiogenesis. We hypothesized that LS inhibits EC migration and tubule formation, 2 functions important in angiogenesis, by inhibiting the secretion of proangiogenic factors.<h4>Methods and results</h4>Human umbilical vein ECs (HUVECs), human microvascula ...[more]