Ontology highlight
ABSTRACT:
SUBMITTER: Liang H
PROVIDER: S-EPMC6208884 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Liang Huichun H Ge Fei F Xu Yuhui Y Xiao Ji J Zhou Zhongmei Z Liu Rong R Chen Ceshi C
Angiogenesis 20180629 4
The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endothelial cells through directly targeting angiopoietin 1 (ANG1) in breast cancer cells. There was a negative correlation between miR-153 and ANG1 levels in breast cancer. miR-153 bloc ...[more]