Ontology highlight
ABSTRACT:
SUBMITTER: Mague SD
PROVIDER: S-EPMC2705603 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Mague Stephen D SD Isiegas Carolina C Huang Peng P Liu-Chen Lee-Yuan LY Lerman Caryn C Blendy Julie A JA
Proceedings of the National Academy of Sciences of the United States of America 20090615 26
A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in a variety of drug addiction and pain sensitivity phenotypes; however, the extent of these adaptations and the mechanisms underlying these associations remain elusive. To clarify the functional mechanisms linking the OPRM1 A118G SNP to addiction and analgesia phenotypes, we derived a mouse model possessing the equivalent nucleotide/amino acid substitution in the ...[more]