Ontology highlight
ABSTRACT:
SUBMITTER: Robinson JE
PROVIDER: S-EPMC4569952 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Robinson J Elliott JE Vardy Eyal E DiBerto Jeffrey F JF Chefer Vladimir I VI White Kate L KL Fish Eric W EW Chen Meng M Gigante Eduardo E Krouse Michael C MC Sun Hui H Thorsell Annika A Roth Bryan L BL Heilig Markus M Malanga C J CJ
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20150416 11
The OPRM1 A118G polymorphism is the most widely studied μ-opioid receptor (MOR) variant. Although its involvement in acute alcohol effects is well characterized, less is known about the extent to which it alters responses to opioids. Prior work has shown that both electrophysiological and analgesic responses to morphine but not to fentanyl are moderated by OPRM1 A118G variation, but the mechanism behind this dissociation is not known. Here we found that humanized mice carrying the 118GG allele ( ...[more]