Interaction of an echinomycin-DNA complex with manganese ions.
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ABSTRACT:
SUBMITTER: Pfoh R
PROVIDER: S-EPMC2705629 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Interaction of an echinomycin-DNA complex with manganese ions.
Pfoh Roland R Cuesta-Seijo Jose A JA Sheldrick George M GM
Acta crystallographica. Section F, Structural biology and crystallization communications 20090627 Pt 7
The crystal structure of an echinomycin-d(ACGTACGT) duplex interacting with manganese(II) was solved by Mn-SAD using in-house data and refined to 1.1 A resolution against synchrotron data. This complex crystallizes in a different space group compared with related complexes and shows a different mode of base pairing next to the bis-intercalation site, suggesting that the energy difference between Hoogsteen and Watson-Crick pairing is rather small. The binding of manganese to N7 of guanine is only ...[more]
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