Ontology highlight
ABSTRACT:
SUBMITTER: Huang Q
PROVIDER: S-EPMC3759973 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
FEBS letters 20080328 10
SNAP-25 has a cysteine cluster located at its linker domain. In vivo, the cysteine residues in this cluster can be palmitoylated, and the hydrophobic palmitate molecules can target SNAP-25 to the presynaptic membrane. Here, we report that the SNAP-25a expressed in Escherichia coli is also an iron-sulfur protein binding an iron-sulfur cluster using the cysteine residues in its cysteine cluster. Therefore, SNAP-25a uses the same cysteine residues to bind two different prosthetic groups (iron-sulfu ...[more]