Ontology highlight
ABSTRACT:
SUBMITTER: Dolakova P
PROVIDER: S-EPMC2706328 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20081002 6
2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines bearing two equal or different achiral or chiral phosphonoalkoxy chains have been prepared either by aromatic nucleophilic substitution of 2-amino-4,6-dichloropyrimidine or by alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine with appropriate phosphonate-bearing building block. Alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine proved to be the method of choice for efficient preparation of variety of bisphosphonates. The enantiome ...[more]