Ontology highlight
ABSTRACT:
SUBMITTER: Bhan S
PROVIDER: S-EPMC2706510 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Bhan Sheetal S May Warren W Warren Stephanie L SL Sittman Donald B DB
Gene 20080216 1-2
In mammals, the functional significance of the presence of evolutionarily conserved, multiple non-allelic H1 variants remains unclear. We used a unique overproduction approach coupled with cell cycle synchronization and early time point assays to assess differential effects of H1 variants, H1c and H1(0), on global gene expression in the absence of compensatory events that may mask variant-specific effects. We found that H1c and H1(0) act primarily as specific rather than global regulators of gen ...[more]