Ontology highlight
ABSTRACT:
SUBMITTER: Town T
PROVIDER: S-EPMC2707901 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Town Terrence T Bai Fengwei F Wang Tian T Kaplan Amber T AT Qian Feng F Montgomery Ruth R RR Anderson John F JF Flavell Richard A RA Fikrig Erol E
Immunity 20090205 2
West Nile virus (WNV), a mosquito-transmitted single-stranded RNA (ssRNA) flavivirus, causes human disease of variable severity. We investigated Toll-like receptor 7-deficient (Tlr7(-/-)) and myeloid differentiation factor 88-deficient (Myd88(-/-)) mice, which both have defective recognition of ssRNA, and found increased viremia and susceptibility to lethal WNV infection. Despite increased tissue concentrations of most innate cytokines, CD45(+) leukocytes and CD11b(+) macrophages failed to home ...[more]