Ontology highlight
ABSTRACT:
SUBMITTER: Ito D
PROVIDER: S-EPMC2708761 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Ito Daisuke D Iizuka Yoshie-Matsubayashi YM Katepalli Madhu P MP Iizuka Koho K
Proceedings of the National Academy of Sciences of the United States of America 20090622 27
NK cells use surface NK receptors to discriminate self from non-self. The NK receptor ligand-binding domain (NKD) has been considered the sole regulator of ligand binding. Using a prototypic murine NK receptor, Ly49A, we show that the membrane proximal nonligand binding ecto-domain (the stalk region) is critical to ligand binding and signaling. The stalk region is required for receptor binding to ligand on target cells (trans interaction), but is dispensable for receptor binding to ligand on the ...[more]