Ontology highlight
ABSTRACT:
SUBMITTER: Asaithamby A
PROVIDER: S-EPMC2709554 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Asaithamby Aroumougame A Chen David J DJ
Nucleic acids research 20090428 12
DNA double-strand breaks (DSBs) are a serious threat to genome stability and cell viability. Although biological effects of low levels of radiation are not clear, the risks of low-dose radiation are of societal importance. Here, we directly monitored induction and repair of single DSBs and quantitatively analyzed the dynamics of interaction of DNA repair proteins at individual DSB sites in living cells using 53BP1 fused to yellow fluorescent protein (YFP-53BP1) as a surrogate marker. The number ...[more]