Ontology highlight
ABSTRACT:
SUBMITTER: Gitter A
PROVIDER: S-EPMC2710864 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Gitter Anthony A Siegfried Zehava Z Klutstein Michael M Fornes Oriol O Oliva Baldo B Simon Itamar I Bar-Joseph Ziv Z
Molecular systems biology 20090616
The complementarity of gene expression and protein-DNA interaction data led to several successful models of biological systems. However, recent studies in multiple species raise doubts about the relationship between these two datasets. These studies show that the overwhelming majority of genes bound by a particular transcription factor (TF) are not affected when that factor is knocked out. Here, we show that this surprising result can be partially explained by considering the broader cellular co ...[more]