Ontology highlight
ABSTRACT:
SUBMITTER: Habib N
PROVIDER: S-EPMC3501536 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Habib Naomi N Wapinski Ilan I Margalit Hanah H Regev Aviv A Friedman Nir N
Molecular systems biology 20120101
Evolutionary rewiring of regulatory networks is an important source of diversity among species. Previous evidence suggested substantial divergence of regulatory networks across species. However, systematically assessing the extent of this plasticity and its functional implications has been challenging due to limited experimental data and the noisy nature of computational predictions. Here, we introduce a novel approach to study cis-regulatory evolution, and use it to trace the regulatory history ...[more]