Ontology highlight
ABSTRACT:
SUBMITTER: Dolloff NG
PROVIDER: S-EPMC2712354 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Dolloff Nathan G NG Shulby Shannon S SS Nelson Autumn V AV Stearns Mark E ME Johannes Gregg J GJ Thomas Jeff D JD Meucci Olimpia O Fatatis Alessandro A
Oncogene 20051001 45
Prostate adenocarcinoma metastasizes to the skeleton more frequently than any other organ. An underlying cause of this phenomenon may be the ability of bone-produced factors to specifically select disseminated prostate cancer cells that are susceptible to their trophic effects. Platelet-derived growth factor (PDGF), a potent mitogen for both normal and tumor cells, is produced in several tissues including bone, where it is synthesized by both osteoblasts and osteoclasts. Here, we show that PDGF ...[more]