Ontology highlight
ABSTRACT:
SUBMITTER: Zolotarev AS
PROVIDER: S-EPMC2712756 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Zolotarev Alexander S AS Unnikrishnan Meera M Shmukler Boris E BE Clark Jeffrey S JS Vandorpe David H DH Grigorieff Nikolaus N Rubin Eric J EJ Alper Seth L SL
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20071223 3
Growth and virulence of mycobacteria requires sulfur uptake. The Mycobacterium tuberculosis genome contains, in addition to the ABC sulfate permease cysTWA, three SLC26-related SulP genes of unknown function. We report that induction of Rv1739c expression in E. coli increased bacterial uptake of sulfate, but not Cl(-), formate, or oxalate. Uptake was time-dependent, maximal at pH 6.0, and exhibited a K(1/2) for sulfate of 4.0 muM. Na(+)-independent sulfate uptake was not reduced by bicarbonate, ...[more]