Ontology highlight
ABSTRACT:
SUBMITTER: Holley CL
PROVIDER: S-EPMC2713440 | biostudies-literature | 2002 Jun
REPOSITORIES: biostudies-literature
Holley Christopher L CL Olson Michael R MR Colón-Ramos Daniel A DA Kornbluth Sally S
Nature cell biology 20020601 6
Inhibitors of apoptosis (IAPs) inhibit caspases, thereby preventing proteolysis of apoptotic substrates. IAPs occlude the active sites of caspases to which they are bound and can function as ubiquitin ligases. IAPs are also reported to ubiquitinate themselves and caspases. Several proteins induce apoptosis, at least in part, by binding and inhibiting IAPs. Among these are the Drosophila melanogaster proteins Reaper (Rpr), Grim, and HID, and the mammalian proteins Smac/Diablo and Omi/HtrA2, all o ...[more]