Ontology highlight
ABSTRACT:
SUBMITTER: Lei W
PROVIDER: S-EPMC7181667 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Lei Wei W Duan Rong R Li Jinbo J Liu Xin X Huston Alissa A Boyce Brendan F BF Yao Zhenqiang Z
Scientific reports 20200424 1
The most challenging issue for breast cancer (BC) patients is metastasis to other organs because current therapies do not prevent or eliminate metastatic BC. Here, we show that SM-164, a small molecule inhibitor, which degrades inhibitor of apoptosis proteins (IAPs), eliminated early-stage metastases and reduced progression of advanced BC metastasis from MDA-MB-231 BC cells in bones and lungs of nude mice. Mechanistically, SM-164-induced BC cell death is TNFα-dependent, with TNFα produced by IL- ...[more]