Ontology highlight
ABSTRACT:
SUBMITTER: Gollmer K
PROVIDER: S-EPMC2713469 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Gollmer Kathrin K Asperti-Boursin François F Tanaka Yoshihiko Y Okkenhaug Klaus K Vanhaesebroeck Bart B Peterson Jeffrey R JR Fukui Yoshinori Y Donnadieu Emmanuel E Stein Jens V JV
Blood 20090518 3
CD4(+) T cells use the chemokine receptor CCR7 to home to and migrate within lymphoid tissue, where T-cell activation takes place. Using primary T-cell receptor (TCR)-transgenic (tg) CD4(+) T cells, we explored the effect of CCR7 ligands, in particular CCL21, on T-cell activation. We found that the presence of CCL21 during early time points strongly increased in vitro T-cell proliferation after TCR stimulation, correlating with increased expression of early activation markers. CCL21 costimulatio ...[more]