A novel putative miRNA target enhancer signal.
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ABSTRACT:
SUBMITTER: Schmidt T
PROVIDER: S-EPMC2714067 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
A novel putative miRNA target enhancer signal.
Schmidt Thorsten T Mewes Hans-Werner HW Stümpflen Volker V
PloS one 20090731 7
It is known that miRNA target sites are very short and the effect of miRNA-target site interaction alone appears as being unspecific. Recent experiments suggest further context signals involved in miRNA target site recognition and regulation. Here, we present a novel GC-rich RNA motif downstream of experimentally supported miRNA target sites in human mRNAs with no similarity to previously reported functional motifs. We demonstrate that the novel motif can be found in at least one third of all tr ...[more]
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