Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates.
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ABSTRACT:
SUBMITTER: Scheller N
PROVIDER: S-EPMC2714764 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
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Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates.
Scheller Nicoletta N Mina Leonardo Bruno LB Galão Rui Pedro RP Chari Ashwin A Giménez-Barcons Mireia M Noueiry Amine A Fischer Utz U Meyerhans Andreas A Díez Juana J
Proceedings of the National Academy of Sciences of the United States of America 20090723 32
Inevitably, viruses depend on host factors for their multiplication. Here, we show that hepatitis C virus (HCV) RNA translation and replication depends on Rck/p54, LSm1, and PatL1, which regulate the fate of cellular mRNAs from translation to degradation in the 5'-3'-deadenylation-dependent mRNA decay pathway. The requirement of these proteins for efficient HCV RNA translation was linked to the 5' and 3' untranslated regions (UTRs) of the viral genome. Furthermore, LSm1-7 complexes specifically ...[more]
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