Ontology highlight
ABSTRACT:
SUBMITTER: Balasubramanian N
PROVIDER: S-EPMC2715295 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Balasubramanian Nagaraj N Scott David W DW Castle J David JD Casanova James E JE Schwartz Martin Alexander MA
Nature cell biology 20071118 12
Integrin-mediated adhesion regulates membrane binding sites for Rac1 within lipid rafts. Detachment of cells from the substratum triggers the clearance of rafts from the plasma membrane through caveolin-dependent internalization. The small GTPase Arf6 and microtubules also regulate Rac-dependent cell spreading and migration, but the mechanisms are poorly understood. Here we show that endocytosis of rafts after detachment requires F-actin, followed by microtubule-dependent trafficking to recyclin ...[more]