Ontology highlight
ABSTRACT:
SUBMITTER: Ma L
PROVIDER: S-EPMC6742330 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Ma Li L Huang Yang Z YZ Pitcher Graham M GM Valtschanoff Juli G JG Ma Ying H YH Feng Lin Y LY Lu Bai B Xiong Wen C WC Salter Michael W MW Weinberg Richard J RJ Mei Lin L
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030401 8
Neuregulin (NRG) regulates synapse formation and synaptic plasticity, but little is known about the regulation of NRG signaling at synapses. Here we show that the NRG receptor ErbB4 was localized in anatomically defined postsynaptic densities in the brain. In cultured cortical neurons, ErbB4 was recruited to the neuronal lipid raft fraction after stimulation by NRG. Along with ErbB4, adaptor proteins Grb2 and Shc were translocated to lipid rafts by NRG stimulation. In transfected human embryonic ...[more]