Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila.
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ABSTRACT:
SUBMITTER: Gilestro GF
PROVIDER: S-EPMC2715914 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila.
Gilestro Giorgio F GF Tononi Giulio G Cirelli Chiara C
Science (New York, N.Y.) 20090401 5923
Sleep is universal, strictly regulated, and necessary for cognition. Why this is so remains a mystery, although recent work suggests that sleep, memory, and plasticity are linked. However, little is known about how wakefulness and sleep affect synapses. Using Western blots and confocal microscopy in Drosophila, we found that protein levels of key components of central synapses were high after waking and low after sleep. These changes were related to behavioral state rather than time of day and o ...[more]
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