Ontology highlight
ABSTRACT:
SUBMITTER: Newman JR
PROVIDER: S-EPMC27203 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Newman J R JR Wolf E E Kim P S PS
Proceedings of the National Academy of Sciences of the United States of America 20001101 24
Computational methods can frequently identify protein-interaction motifs in otherwise uncharacterized open reading frames. However, the identification of candidate ligands for these motifs (e.g., so that partnering can be determined experimentally in a directed manner) is often beyond the scope of current computational capabilities. One exception is provided by the coiled-coil interaction motif, which consists of two or more alpha helices that wrap around each other: the ligands for coiled-coil ...[more]