Ontology highlight
ABSTRACT:
SUBMITTER: Gallego O
PROVIDER: S-EPMC3010107 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Molecular systems biology 20101101
Protein-metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein-lipid interactions in yeast. We used arrays of 56 metabolites to measure lipid-binding fingerprints of 172 proteins, including 91 with predicted lipid-binding domains. We identified 530 protein-lipid associations, the majority of which are novel. To show the data set's biological value, we studied further several novel interactions with sphingolipids, a clas ...[more]