Ontology highlight
ABSTRACT:
SUBMITTER: Wei G
PROVIDER: S-EPMC2722509 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Wei Gang G Wei Lai L Zhu Jinfang J Zang Chongzhi C Hu-Li Jane J Yao Zhengju Z Cui Kairong K Kanno Yuka Y Roh Tae-Young TY Watford Wendy T WT Schones Dustin E DE Peng Weiqun W Sun Hong-Wei HW Paul William E WE O'Shea John J JJ Zhao Keji K
Immunity 20090101 1
Multipotential naive CD4(+) T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4(+) T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or plasticity in T cell responses. We generated genome-wide histone H3 lysine 4 (H3K4) and lysine 27 (H3K27) trimethylation maps in naive, Th1, Th2, Th17, iTreg, and natural Treg (nTr ...[more]