Ontology highlight
ABSTRACT:
SUBMITTER: Kinkley S
PROVIDER: S-EPMC4992058 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kinkley Sarah S Helmuth Johannes J Polansky Julia K JK Dunkel Ilona I Gasparoni Gilles G Fröhler Sebastian S Chen Wei W Walter Jörn J Hamann Alf A Chung Ho-Ryun HR
Nature communications 20160817
The combinatorial action of co-localizing chromatin modifications and regulators determines chromatin structure and function. However, identifying co-localizing chromatin features in a high-throughput manner remains a technical challenge. Here we describe a novel reChIP-seq approach and tailored bioinformatic analysis tool, normR that allows for the sequential enrichment and detection of co-localizing DNA-associated proteins in an unbiased and genome-wide manner. We illustrate the utility of the ...[more]