Ontology highlight
ABSTRACT:
SUBMITTER: Bodnar RJ
PROVIDER: S-EPMC2723158 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Bodnar Richard J RJ Yates Cecelia C CC Rodgers Margaret E ME Du Xiaoping X Wells Alan A
Journal of cell science 20090526 Pt 12
The signals that prune the exuberant vascular growth of tissue repair are still ill defined. We demonstrate that activation of CXC chemokine receptor 3 (CXCR3) mediates the regression of newly formed blood vessels. We present evidence that CXCR3 is expressed on newly formed vessels in vivo and in vitro. CXCR3 is expressed on vessels at days 7-21 post-wounding, and is undetectable in unwounded or healed skin. Treatment of endothelial cords with CXCL10 (IP-10), a CXCR3 ligand present during the re ...[more]