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Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor.

ABSTRACT: We describe an electrochemical analog of fluorescence polarization that supports the quantitative measurement of a specific protein, the chemokine IP-10, directly in undiluted blood serum. The sensor is label-free, wash-free, and electronic, suggesting it could support point-of-care detection of diagnostic proteins in largely unprocessed clinical samples.

SUBMITTER: Bonham AJ 

PROVIDER: S-EPMC3956051 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor.

Bonham Andrew J AJ   Paden Nicole G NG   Ricci Francesco F   Plaxco Kevin W KW  

The Analyst 20131001 19

We describe an electrochemical analog of fluorescence polarization that supports the quantitative measurement of a specific protein, the chemokine IP-10, directly in undiluted blood serum. The sensor is label-free, wash-free, and electronic, suggesting it could support point-of-care detection of diagnostic proteins in largely unprocessed clinical samples. ...[more]

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