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Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

ABSTRACT: Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

SUBMITTER: Wu Y

PROVIDER: S-EPMC2723842 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

Wu Yunkou Y Zhou Youfu Y Ouari Olivier O Woods Mark M Zhao Piyu P Soesbe Todd C TC Kiefer Garry E GE Sherry A Dean AD

Journal of the American Chemical Society 20080926 42

Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging. ...[more]

PMID: 18817395

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