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Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

ABSTRACT: Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

SUBMITTER: Wu Y 

PROVIDER: S-EPMC2723842 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

Wu Yunkou Y   Zhou Youfu Y   Ouari Olivier O   Woods Mark M   Zhao Piyu P   Soesbe Todd C TC   Kiefer Garry E GE   Sherry A Dean AD  

Journal of the American Chemical Society 20080926 42

Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging. ...[more]

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