A model system for analyzing somatic mutations in Drosophila melanogaster.
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SUBMITTER: Garcia AM
PROVIDER: S-EPMC2723853 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
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A model system for analyzing somatic mutations in Drosophila melanogaster.
Garcia Ana Maria AM Derventzi Anastasia A Busuttil Rita R Calder R Brent RB Perez Ernesto E Chadwell Linda L Dollé Martijn E T ME Lundell Martha M Vijg Jan J
Nature methods 20070415 5
Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements. ...[more]
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