Ontology highlight
ABSTRACT:
SUBMITTER: Garcia AM
PROVIDER: S-EPMC2869313 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
PLoS genetics 20100513 5
Using a transgenic mouse model harboring a mutation reporter gene that can be efficiently recovered from genomic DNA, we previously demonstrated that mutations accumulate in aging mice in a tissue-specific manner. Applying a recently developed, similar reporter-based assay in Drosophila melanogaster, we now show that the mutation frequency at the lacZ locus in somatic tissue of flies is about three times as high as in mouse tissues, with a much higher fraction of large genome rearrangements. Sim ...[more]