Ontology highlight
ABSTRACT:
SUBMITTER: Kumarevel T
PROVIDER: S-EPMC2724296 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Kumarevel Thirumananseri T Tanaka Tomoyuki T Umehara Takashi T Yokoyama Shigeyuki S
Nucleic acids research 20090609 14
ST1710, a member of the multiple antibiotic resistance regulator (MarR) family of regulatory proteins in bacteria and archaea, plays important roles in development of antibiotic resistance, a global health problem. Here, we present the crystal structure of ST1710 from Sulfolobus tokodaii strain 7 complexed with salicylate, a well-known inhibitor of MarR proteins and the ST1710 complex with its promoter DNA, refined to 1.8 and 2.10 A resolutions, respectively. The ST1710-DNA complex shares the to ...[more]